Treating To Target in Type 2 Diabetes

Do Glycoalbumin Levels Preferentially Reflect Changes in Postprandial Glucose Excursions?
S. K. Paul and R. R. Holman
Diab Med. 2017;34:1284–1290. Published:Sep-2017. Epub:13-Jun-2017. PMID:28477414. doi:10.1111/dme.13376

Continuous Glucose Monitoring Detected Hypoglycaemia in the Treating to Target in Type 2 Diabetes Trial (4-T)
JC Levy, MJ Davies, RR Holman, for the 4-T Study Group
Diabetes Res Clin Pract. 2017;131:161–168. Published:Sep-2017. Epub:21-Mar-2017. PMID:28750219. doi:10.1016/j.diabres.2017.01.022

Disseminating results to clinical trial participants: a qualitative review of patient understanding in a post-trial population
Julie Lorraine Darbyshire, Hermione Clare Price
BMJ Open 2012;2:e001252. Published:24-Sep-2012. PMID:23012330. doi:10.1136/bmjopen-2012-001252

Understanding the outcomes of multi-centre clinical trials: a qualitative study of health professional experiences and views
Lawton J, Jenkins N, Darbyshire J, Farmer A, Holman R, Hallowell N
Social Science & Medicine 2012;74:574-81. Published:Feb-2012. Epub:23-Dec-2011. PMID:22236642. doi:10.1016/j.socscimed.2011.11.012

Differences in insulin treatment satisfaction following randomized addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes
Farmer AJ, Oke J, Stevens R, Holman RR
Diabetes, Obesity and Metabolism 2011;13:1136-1141. Published:16-Nov-2011. PMID:21767341. doi:10.1111/j.1463-1326.2011.01475.x

Challenges of maintaining research protocol fidelity in a clinical care setting: A qualitative study of the experiences and views of patients and staff participating in a randomized controlled trial
Julia Lawton, Nicholas Jenkins, Julie L Darbyshire, Rury R Holman, Andrew J Farmer and Nina Hallowell
Trials 2011;12: . Published:04-May-2011. PMID:21542916. doi:10.1186/1745-6215-12-108

Participants' experiences of intensifying insulin therapy during the Treating to Target in Type 2 Diabetes (4-T) trial: qualitative interview study
N. Jenkins, N. Hallowell, A. J. Farmer, R. R. Holman, J. Lawton
Diab Med. 2011;28:543-548. Published:May-2011. PMID:21480965. doi:10.1111/j.1464-5491.2010.03200.x

Initiating insulin as part of the Treating to Target in Type 2 Diabetes (4-T) trial: A interview study of patients' and health care professionals' experiences
Nicholas Jenkins, Nina Hallowell, Andrew J. Farmer, Rury R. Holman, Julia Lawton
Diabetes Care 2010;33:2178-2180. Published:Oct-2010. Epub:30-Jun-2010. PMID:20592050. doi:10.2337/dc10-0494

Insulin Regimens in Type 2 Diabetes - Authors' reply
Rury R. Holman, Julie L. Darbyshire,
N Engl J Med 2010;362:960. Published:11-Mar-2010. PMID:20220196. doi:10.1056/NEJMc0911551

Three-Year Efficacy of Complex Insulin Regimens in Type 2 Diabetes
Rury R. Holman, Andrew J. Farmer, Melanie J. Davies, Jonathan C. Levy, Julie L. Darbyshire, Joanne F. Keenan, and Sanjoy K. Paul for the 4-T Study Group
N Eng J Med 2009;361:1736-47. Published:29-Oct-2009. Epub:22-Oct-2009. PMID:19850703. doi:10.1056/NEJMoa0905479
[Slides]

Presenting the results of clinical trials to participants
Julie L Darbyshire, Rury R Holman and Hermione C Price
Clin Med (Lond). 2009;9:415-416. Published:Oct-2009. PMID:19886097. doi:10.7861/clinmedicine.9-5-415

Addition of Insulin to Oral Therapy in Type 2 Diabetes - Author's reply
Holman RR
N Eng J Med 2008;358:1198. Published:13-Mar-2008. PMID:18337612. doi:10.1056/NEJMc073240

Addition of Biphasic, Prandial, or Basal Insulin to Oral Therapy in Type 2 Diabetes
Rury R. Holman, Kerensa I. Thorne, Andrew J. Farmer, Melanie J. Davies, Joanne F. Keenan, Sanjoy Paul, Jonathan C. Levy for the 4-T Study Group
N Eng J Med 2007;357:1716-30. Published:25-Oct-2007. Epub:21-Sep-2007. PMID:17890232. doi:10.1056/NEJMoa075392
[Abstract] [Slides]