Manuscripts (106 of 545)

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A brief history of the UK Prospective Diabetes Study
Rury Holman, for the UKPDS Group
Br J Diabetes 2022;22:S32-S35. Published:Dec-2022. doi:10.15277/bjd.2022.359


Estimating risk factor progression equations for the UKPDS Outcomes Model 2 (UKPDS 90)
Jose Leal, Maria Alva, Vanessa Gregory, Alison Hayes, Borislava Mihaylova, Alastair M Gray, Rury R. Holman, Philip Clarke
Diabet Med. 2021;38:e14656. Published:Oct-2021. Epub:23-Jul-2021. PMID:34297424. doi:10.1111/dme.14656

Historical HbA1c Values May Explain the Type 2 Diabetes Legacy Effect: UKPDS 88
Marcus Lind, Henrik Imberg, Ruth L. Coleman, Olle Nerman, and Rury R. Holman
Diabetes Care 2021;44:2231-2237. Published:Oct-2021. Epub:08-Jul-2021. PMID:34244332. doi:10.2337/dc20-2439

Increased Risk of Incident Heart Failure and Death is Associated with Insulin Resistance in People with Newly- Diagnosed Type 2 Diabetes: UKPDS 89
Malgorzata Wamil, Ruth L. Coleman, Amanda I. Adler, John McMurray, Rury R. Holman
Diabetes Care 2021;44:1-8. Published:Aug-2021. PMID:341626. doi:10.2337/dc21-0429


Long-term glucose variability and risk of nephropathy complication in UKPDS, ACCORD and VADT trials
Jin J. Zhou, Ruth Coleman, Rury R. Holman, Peter Reaven
Diabetologia 2020;63:2482-2485. Published:Nov-2020. Epub:21-Sep-2020. PMID:32954444. doi:10.1007/s00125-020-05273-7

Predicting Post One-year Durability of Glucose-lowering Monotherapies in Patients with Newly-diagnosed Type 2 Diabetes Mellitus - A MASTERMIND Precision Medicine Approach (UKPDS 87)
Olorunsola F. Agbaje, Ruth L. Coleman, Andrew T. Hattersley, Angus G. Jones, Ewan R. Pearson, Beverley M. Shields, and Rury R. Holman, for the MASTERMIND consortium
Diabetes Res Clin Pract. 2020;166:108333. Published:Aug-2020. Epub:20-Jul-2020. PMID:32702468. doi:10.1016/j.diabres.2020.108333

Time-varying risk of microvascular complications in latent autoimmune diabetes of adulthood compared with type 2 diabetes in adults: a post-hoc analysis of the UK Prospective Diabetes Study 30-year follow-up data (UKPDS 86)
Ernesto Maddaloni, Ruth L. Coleman, Olorunsola F. Agbaje, Raffaella Buzzetti, Rury R. Holman
Lancet Diabetes Endocrinol 2020;8:206-15. Published:Mar-2020. Epub:04-Feb-2020. PMID:32032540. doi:10.1016/S2213-8587(20)30003-6


Long-term Risk of Cardiovascular Disease in Individuals with Latent Autoimmune Diabetes of Adults (UKPDS 85)
E. Maddaloni, R.L.Coleman, P.Pozzilli, R.R. Holman
Diabetes Obese Metab. 2019;2019:2115-2122. Epub:17-May-2019. PMID:31099472. doi:10.1111/dom.13788


The impact of diabetes-related complications on healthcare costs: new results from the UKPDS (UKPDS 84)
M. L. Alva, A. Gray, B. Mihaylova, J. Leal and R. R. Holman
Diab Med. 2015;32:459-466. Published:Apr-2015. Epub:07-Jan-2015. PMID:25439048. doi:10.1111/dme.12647


Performance of the UKPDS Outcomes Model for Prediction of Myocardial Infarction and Stroke in the ADDITION-Europe Trial Cohort: does the ADDITION validation add up? – Authors' reply
Alastair Gray, Rury Holman, Philip Clarke, Jose Leal
Value in Health 2014;17:895-6. Published:Dec-2014. Epub:22-Sep-2014. PMID:25498785. doi:10.1016/j.jval.2014.07.008

Ethnicity and long-term vascular outcomes in Type 2 diabetes: a prospective observational study (UKPDS 83)
T. M. E. Davis, R. L. Coleman and R. R. Holman for the UKPDS Group
Diab Med. 2014;31:200-207. Published:Feb-2014. Epub:22-Nov-2013. PMID:24267048. doi:10.1111/dme.12353


UKPDS - The first 30 years (Chinese version)
Holman RR, Watkins PJ
2013; . Published:18-Nov-2013

UKPDS Outcomes Model 2: a new version of a model to simulate lifetime health outcomes of patients with type 2 diabetes mellitus using data from the 30 year United Kingdom Prospective Diabetes Study: UKPDS 82
Hayes AJ, Leal J, Gray AM, Holman RR, Clarke PM
Diabetologia 2013;56:1925-1933. Published:Sep-2013. Epub:22-Jun-2013. PMID:23793713. doi:10.1007/s00125-013-2940-y

Temporal Validation of the UKPDS Outcomes Model Using 10-Year Post trial Monitoring Data
Leal J, Hayes AJ, Gray AM, Holman RR, Clarke PM.
Diabetes Care 2013;36:1541-1546. Published:Jun-2013. Epub:28-Dec-2012. PMID:23275370. doi:10.2337/dc12-1120

Prognostic Significance of Silent Myocardial Infarction in Newly-Diagnosed Type 2 Diabetes: UKPDS 79
Timothy M.E. Davis; Ruth L. Coleman; Rury R. Holman
Circulation 2013;127:980-987. Published:05-Mar-2013. Epub:29-Jan-2013. PMID:23362315. doi:10.1161/CIRCULATIONAHA.112.000908


Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
The GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group & The Wellcome Trust Case Control Consortium
Nature Genetics 2010;43:117-120. Published:Feb-2011. Epub:26-Dec-2010. PMID:21186350. doi:10.1038/ng.735


Performance of the UKPDS Risk Engine and the Framingham risk equations in estimating cardiovascular disease in the EPIC-Norfolk cohort
Simmons RK, Coleman RL, Price HC, Holman RR, Khaw K, Wareham NJ, Griffin SJ
Diabetes Care 2009;32:708-713. Published:Apr-2009. Epub:29-Dec-2008. PMID:19114615. doi:10.2337/dc08-1918


10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
Rury R. Holman, Sanjoy K. Paul, M. Angelyn Bethel, David R. Matthews and H. Andrew W. Neil
N Eng J Med 2008;359:1577-89. Published:09-Oct-2008. Epub:10-Sep-2008. PMID:18784090. doi:10.1056/nejmoa0806470

Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes
Rury R. Holman, Sanjoy K. Paul, M. Angelyn Bethel, H. Andrew W. Neil and David R. Matthews
N Eng J Med 2008;359:1565-76. Published:09-Oct-2008. Epub:10-Sep-2008. PMID:18784091. doi:10.1056/nejmoa0806359

UKPDS - The first 30 years
Holman RR, Watkins PJ
Diab Med. 2008;25 (Suppl. 2):1


Impact of the metabolic syndrome on macrovascular and microvascular outcomes in type 2 diabetes mellitus: United Kingdom Prospective Diabetes Study 78
Carole A. Cull, Christine C. Jensen, Ravi Retnakaran and Rury R. Holman
Circulation 2007;116:2119-2126. Published:06-Nov-2007. Epub:22-Oct-2007. PMID:17967769. doi:10.1161/CIRCULATIONAHA.107.733428

GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77.
M. Desai, C. A. Cull, V. A. Horton, M. R. Christie, E. Bonifacio, V. Lampasona, P. J. Bingley, J. C. Levy, I. R. Mackay, P. Zimmet, R. R. Holman and A. Clark
Diabetologia 2007;50:2052-2060. Published:Oct-2007. Epub:27-Jul-2007. PMID:17657474. doi:10.1007/s00125-007-0745-6

Metformin as First Choice in oral Diabetes Treatment: the UKPDS experience
Holman R
Journ Annu Diabetol Hotel Dieu 2007;13:13-20. Published:Jan-2007. PMID:18613325
[Full text]


Paraoxonase2 (PON2) Polymorphisms and Development of Renal Dysfunction in Type 2 Diabetes: UKPDS 76
Calle R, McCarthy MI, Banerjee P, Zeggini E, Cull CA, Thorne KI, Wiltshire S, Terra S, Meyer D, Richmond J, Mancuso J, Milos P, Fryburg D, Holman RR
Diabetologia 2006;49:2892-2899. Published:Dec-2006. Epub:03-Oct-2006. PMID:17096118. doi:10.1007/s00125-006-0436-8

Hypoglycemia in Type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS 73
Wright AD, Cull CA, Macleod KM, Holman RR for the UKPDS Group
J Diabetes Complications 2006;20:402-408. Published:Nov-2006. Epub:25-Oct-2006. PMID:17070446. doi:10.1016/j.jdiacomp.2005.08.010

Additive effects of glycaemia and blood pressure exposure on risk of complications in type 2 diabetes: a prospective observational study (UKPDS 75)
Stratton IM, Cull CA, Adler AI, Matthews DR, Neil HA, Holman RR
Diabetologia 2006;49:1761-1769. Published:Aug-2006. Epub:31-May-2006. PMID:16736131. doi:10.1007/s00125-006-0297-1

Risk Factors for Renal Dysfunction in Type 2 Diabetes
Retnakaran R, Cull CA, Thorne KI, Adler AI, Holman RR for the UKPDS study group
Diabetes 2006;55:1832-1839. Published:Jun-2006. PMID:16731850. doi:10.2337/db05-1620


Cost-utility analyses of intensive blood glucose and tight blood pressure control in type 2 diabetes (UKPDS 72)
Clarke PM, Gray AM, Briggs A, Stevens RJ, Matthews DR, Holman RR
Diabetologia 2005;48:868-877. Published:May-2005. Epub:15-Apr-2005. PMID:15834550. doi:10.1007/s00125-005-1717-3

IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes
G. F. Bottazzo, E. Bosi, C. A. Cull, E. Bonifacio, M. Locatelli, P. Zimmet, I. R. Mackay, R. R. Holman
Diabetologia 2005;48:703-708. Published:Apr-2005. Epub:12-Mar-2005. PMID:15765222. doi:10.1007/s00125-005-1691-9
Erratum in :
Diabetologia 2005;48:1240, Epub:19-May-2005, doi:10.1007/s00125-005-1808-1

Islet autoantibodies in clinically diagnosed type 2 diabetes: prevalence and relationship with metabolic control
T. M. E. Davis, A. D. Wright, Z. M. Mehta, C. A. Cull, I. M. Stratton, G. F. Bottazzo, E. Bosi, I. R. Mackay, R. R. Holman
Diabetologia 2005;48:695-702. Published:Apr-2005. Epub:24-Feb-2005. PMID:15729570. doi:10.1007/s00125-005-1690-x

Insulin sensitivity at diagnosis of Type 2 diabetes is not associated with subsequent cardiovascular disease (UKPDS 67)
Adler AI, Levy JC, Matthews DR, Stratton IM, Hines G, Holman RR
Diab Med. 2005;22:306-311. Published:Mar-2005. Epub:02-Dec-2004. PMID:15717879. doi:10.1111/j.1464-5491.2004.01418.x


Changing aspirin use in patients with Type 2 diabetes in the UKPDS
Cull CA, Neil HAW, Holman RR
Diab Med. 2004;21:1368-1371. Published:Dec-2004. Epub:24-Nov-2004. PMID:15569143. doi:10.1111/j.1464-5491.2004.01328.x

Risks of progression of retinopathy and vision loss related to tight blood pressure control in type 2 diabetes mellitus
Matthews DR, Stratton IM, Aldington SJ, Holman RR, Kohner EM for the UK Prospective Diabetes Study Group
Archives of Ophthalmology 2004;122:1631-1640. Published:Nov-2004. PMID:15534123. doi:10.1001/archopht.122.11.1631

A model to estimate the lifetime health outcomes of patients with type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS 68)
P. M. Clarke, A. M. Gray, A. Briggs, A. J. Farmer, P. Fenn, R. J. Stevens, D. R. Matthews, I. M. Stratton, R. R. Holman
Diabetologia 2004;47:1747-1759. Published:Oct-2004. Epub:27-Oct-2004. PMID:15517152. doi:10.1007/s00125-004-1527-z

Risk factors for myocardial infarction case fatality and stroke case fatality in type 2 diabetes: UKPDS 66
Stevens RJ, Coleman RL, Adler AI, Stratton IM, Matthews DR, Holman RR
Diabetes Care 2004;27:201-207. Published:Jan-2004. PMID:14693990. doi:10.2337/diacare.27.1.201


The impact of diabetes-related complications on healthcare costs: results from the United Kingdom Prospective Diabetes Study (UKPDS Study No 65)
Clarke P, Gray A, Legood R, Briggs A, Holman R
Diab Med. 2003;20:442-450. Published:Jun-2003. Epub:18-Jul-2003. PMID:12786677. doi:10.1046/j.1464-5491.2003.00972.x

Development and progression of nephropathy in type 2 diabetes: The United Kingdom Prospective Diabetes Study (UKPDS 64)
Adler AI, Stevens RJ, Manley SE, Bilous RW, Cull CA, Holman RR for the UKPDS Group
Kidney International 2003;63:225-232. Published:Jan-2003. PMID:12472787. doi:10.1046/j.1523-1755.2003.00712.x


Modeling glucose exposure as a risk factor for photocoagulation in type 2 diabetes.
Stevens RJ, Stratton IM, Holman RR.
J Diabetes Complications 2002;16:371-376. Published:Nov-2002. Epub:04-Dec-2002. PMID:12477619. doi:10.1016/S1056-8727(02)00161-7

The economics of translating trial evidence into practice: costs of implementing more intensive glycaemic and blood pressure control in type 2 diabetes in England
Gray A, Clarke P, Farmer A, Holman R for the United Kingdom Prospective Diabetes Study (UKPDS) Group
BMJ 2002;325:860. Published:19-Oct-2002. PMID:12386035. doi:10.1136/bmj.325.7369.860

Are Lower Fasting Plasma Glucose Levels at Diagnosis of Type 2 Diabetes Associated with Improved Outcomes?
Colagiuri S, Cull CA, Holman RR
Diabetes Care 2002;25:1410-1417. Published:Aug-2002. PMID:12145243. doi:10.2337/diacare.25.5.894

Estimating utility values for health states of type 2 diabetic patients using the EQ-5D
Clarke P, Gray A, Holman R
Medical Decision Making 2002;4:340-349. Published:Aug-2002. PMID:12150599. doi:10.1177/0272989X0202200412

Risk of Stroke in Type 2 Diabetes Estimated by the UK Prospective Diabetes Study Risk Engine
Kothari V, Stevens RJ, Adler AI, Stratton IM, Manley SE, Neil HA, Holman RR
Stroke 2002;33:1776-1781. Published:Jul-2002. PMID:12105351. doi:10.1161/01.STR.0000020091.07144.C7

Hyperglycemia and Other Potentially Modifiable Risk Factors for Peripheral Vascular Disease in Type 2 Diabetes.
Adler AI, Stevens RJ, Neil A, Stratton IM, Boulton AJ, Holman RR
Diabetes Care 2002;25:894-899. Published:May-2002. PMID:11978687. doi:10.2337/diacare.25.5.894

Sulfonylurea inadequacy: efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the U.K. Prospective Diabetes Study (UKPDS 57)
Wright A, Burden ACF, Paisey RB, Cull CA, Holman RR.
Diabetes Care 2002;25:330-336. Published:Feb-2002. PMID:11815505. doi:10.2337/diacare.25.2.330
Erratum in :
Diabetes Care 2002;25:1268, Print:Jul-2002, doi:10.2337/diacare.25.7.1268

Calculation of coronary risk in Type II diabetes: another cause for concern: authors' reply
Holman RR, Manley SE, Stevens RJ on behalf of the UKPDS Study Group
Clin Sci (Lond). 2002;103:217-219. Published:01-Aug-2001. PMID:12149114. doi:10.1042/cs1030217v


The UKPDS: implications for the dyslipidaemic patient
Holman R
Acta Diabetologica 2001;38 Suppl 1:S9-S14. Published:Sep-2006. PMID:11829452. doi:10.1007/s005920170003

The UKPDS Risk Engine: a model for the risk of coronary heart disease in type 2 diabetes
Richard J. STEVENS, Viti KOTHARI, Amanda I. ADLER, Irene M. STRATTON and Rury R. HOLMAN on behalf of the United Kingdom Prospective Diabetes Study (UKPDS) Group
Clin Sci (Lond). 2001;101:671-679. Published:Dec-2001. PMID:11724655. doi:10.1042/cs1010671
Erratum in :
Clin Sci (Lond). 2002;102:679, Print:Jun-2002, doi:10.1042/cs1020679

Relationship between ethnicity and glycaemic control, lipid profiles and blood pressure during the first nine years of Type 2 diabetes
Davis TM, Cull CA, Holman RR; U.K. Prospective Diabetes Study (UKPDS) Group
Diabetes Care 2001;24:1167-1173. Published:Jul-2001. PMID:11423497. doi:10.2337/diacare.24.7.1167

An economic evaluation of atenolol versus captopril in patients with Type 2 diabetes (UKPDS 54)
Gray A, Clarke P, Raikou M, Stevens R, Neil A, Cull C, Stratton I, Holman R
Diab Med. 2001;18:438-444. Published:Jun-2001. Epub:20-Dec-2001. PMID:11472461. doi:10.1046/j.1464-5491.2001.00485.x

Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)
Gloyn AL, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S, Turner RC.
Diab Med. 2001;18:206-12. Published:Mar-2001. Epub:20-Dec-2001. PMID:11318841. doi:10.1046/j.1464-5491.2001.00449.x
Erratum in :
Diab Med. 2003;20:252, Print:Mar-2003

Relationship between the severity of retinopathy and progression to photocoagulation in patients with Type 2 diabetes mellitus in the UKPDS (UKPDS 52)
Kohner EM, Stratton IM, Aldington SJ, Holman RR, Matthews DR.
Diab Med. 2001;18:178-184. Published:Mar-2001. Epub:20-Dec-2001. PMID:11318837. doi:10.1046/j.1464-5491.2001.00458.x

Cost-effective analysis of intensive blood glucose control with metformin in overweight patients with type 2 diabetes (UKPDS 51).
Clarke P, Gray A, Adler A, Stevens R, Raikou M, Cull C, Stratton I, Holman R; UKPDS Group. United Kingdom Prospective Diabetes Study
Diabetologia 2001;44:298-304. Published:Mar-2001. PMID:11317659. doi:10.1007/s001250051617

UKPDS 50: risk factors for incidence and progression of retinopathy in Type II diabetes over 6 years from diagnosis
Stratton IM, Kohner EM, Aldington SJ, Turner RC, Manley SE, Matthews DR
Diabetologia 2001;44:1546-163. Published:Feb-2001. PMID:11270671. doi:10.1007/s001250051594


Life-expectancy projection by modelling and computer simulation (UKPDS 46)
Stevens R, Adler A, Gray A, Briggs A, Holman R.
Diabetes Res Clin Pract. 2000;50 (Suppl 3):S5-S13. Published:Nov-2000. Epub:13-Nov-2000. PMID:11080560. doi:10.1016/S0168-8227(00)00214-X

Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study
Adler AI, Stratton IM, Neil HA, Yudkin JS, Matthews DR, Cull CA, Wright AD, Turner RC, Holman RR
British Medical Journal 2000;321:412-419. Published:12-Aug-2000. PMID:10938049. doi:10.1136/bmj.321.7258.412
[Abstract] [Slides]
Erratum in :
British Medical Journal 2001;322:90, Print:13-Jan-2001

Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR
British Medical Journal 2000;321:405-412. Published:12-Aug-2000. PMID:10938048. doi:10.1136/bmj.321.7258.405
[Abstract] [Slides]

Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study
Adler AI, Stratton IM, Neil HA, Yudkin JS, Matthews DR, Cull CA, Wright AD, Turner RC, Holman RR
British Medical Journal 2000;321:412-419. Published:12-Aug-2000. PMID:10938049. doi:10.1136/bmj.321.7258.412
[Abstract] [Slides]
Erratum in :
British Medical Journal 2001;322:90, Print:13-Jan-2001

Effects of three months' diet after diagnosis of type 2 diabetes on plasma lipids and lipoproteins
Manley SM, Stratton IM, Cull CA, Fighi V, Eeley EA, Matthews DR, Holman RR, Turner RC
Diab Med. 2000;17:518-23. Published:Jul-2000. PMID:10972581. doi:10.1046/j.1464-5491.2000.00320.x

Cost-effective analysis of intensive blood glucose control with metformin in overweight patients with type 2 diabetes.
Gray A, Raikou M, McGuire A, Fenn P, Stevens R, Cull C, Stratton I, Adler A, Holman R, Turner R
British Medical Journal 2000;320:1373-1378. Published:20-May-2000. PMID:10818026. doi:10.1136/bmj.320.7246.1373


Hyperglycemia and hyperinsulinemia at diagnosis of diabetes and their association with subsequent cardiovascular disease in the United Kingdom prospective diabetes study (UKPDS 47)
Adler AI, Neil AW, Manley SE, Holman RR, Turner RC
Am Heart J 1999;138 (5 Pt 1):S353-9. Published:11-Sep-2006. PMID:10539797. doi:10.1016/S0002-8703(99)70035-9

Sequence variants of the sarco(endo)plasmic reticulum Ca2+-transport ATPase 3 gene (SERCA3) are associated with Type 2 diabetes in Caucasians
Varadi A, Lebel L, Hashim Y, Mehta Z, Ashcroft SJH, Turner RC
Diabetologia 1999;42:1240-1243. Published:Sep-1999. PMID:10525666. doi:10.1007/s001250051298

Microaneurysms in the development of diabetic retinopathy
Kohner EM, Stratton IM, Adlington SJ, Turner RC
Diabetologia 1999;42:1107-1112. Published:Sep-1999. PMID:10447523. doi:10.1007/s001250051278

UKPDS: What was the question? UK Prospective Diabetes Study
Turner R, Holman R, Butterfield J
Lancet 1999;354:600. Published:14-Aug-1999. PMID:10470732. doi:10.1016/S0140-6736(05)77957-5

Randomised, double-blind trial of acarbose in type 2 diabetes shows improved glycaemic control over three years
Holman RR, Cull CA, Turner RC
Diabetes Care 1999;22:960-964. Published:Jul-1999. PMID:10372249. doi:10.2337/diacare.22.6.960
Erratum in :
Diabetes Care 1999;22:1922, Print:Nov-1999

Quality of life in type 2 diabetic patients is affected by complications but not by intensive policies to improve blood glucose or blood pressure control
Diabetes Care 1999;22:1125-1136. Published:Jul-1999. PMID:10388978. doi:10.2337/diacare.22.7.1125

Glycemic Control With Diet, Sulfonylurea, Metformin, or Insulin in Patients With Type 2 Diabetes Mellitus: Progressive Requirement for Multiple Therapies (UKPDS 49)
Turner RC, Cull CA, Frighi V, Holman RR
JAMA 1999;281:2005-2012. Published:02-Jun-1999. PMID:10359389. doi:10.1001/jama.281.21.2005

Risk factors for stroke in non-insulin dependent diabetes mellitus
Davies TME, Millns H, Stratton IM, Holman RR, Turner RC
Arch Intern Med 1999;159:1097-1103. Published:24-May-1999. PMID:10335687. doi:10.1001/archinte.159.10.1097

Genetic heterogeneity of autoimmune diabetes: age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43). UK Prospective Diabetes Study (UKPDS) Group
Horton VA, Stratton IM, Bottazzo GF, Shattock M, MacKay I, Zimmett P, Manley SE, Holman RR, Turner RC
Diabetologia 1999;42:608-616. Published:May-1999. PMID:10333055. doi:10.1007/s001250051202

Hepatocyte nuclear factor-1alpha (the MODY3 gene) mutations in late onset Type 2 diabetes in the UK.
Cox RD, Sotham L, Hashim Y, Horton V, Mehta Z, Taghavi J, Lathrop M, Turner RC
Diabetes 1999;42:120-121. Published:Jan-1999. PMID:10027593. doi:10.1007/s001250051127


Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
BMJ 1998;317:703-713. Published:12-Sep-1998. PMID:9732337. doi:10.1136/bmj.317.7160.703

Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. UK Prospective Diabetes Study Group
BMJ 1998;317:713-720. Published:12-Sep-1998. PMID:9732338. doi:10.1136/bmj.317.7160.713

Cost effectiveness analysis of improved blood pressure control in hypertensive patients with type 2 diabetes
British Medical Journal 1998;317:720-726. Published:12-Sep-1998. PMID:9732339. doi:10.1136/bmj.317.7160.720

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
Lancet 1998;352:837-853. Published:12-Sep-1998. PMID:9742976. doi:10.1016/S0140-6736(98)07019-6
Erratum in :
Lancet 1999;354:602, Print:14-Aug-1999

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
Lancet 1998;352:854-865. Published:12-Sep-1998. PMID:9742977. doi:10.1016/S0140-6736(98)07037-8
Erratum in :
Lancet 1998;352:1558, Print:07-Nov-1998, doi:10.1016/S0140-6736(05)60381-9

Ethnicity and cardiovascular disease. The incidence of myocardial infarction in white, South Asian, and Afro-Caribbean patients with type 2 diabetes (U.K. Prospective Diabetes Study 32)
Diabetes Care 1998;21:1271-1277. Published:Aug-1998. PMID:9702432. doi:10.2337/diacare.21.8.1271

UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years
Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC
Diab Med. 1998;15:297-303. Published:Apr-1998. PMID:9585394. doi:10.1002/(SICI)1096-9136(199804)15:4<297::AID-DIA572>3.0.CO;2-W

Risk factors for coronary artery disease in non-insulin dependent diabetes
British Medical Journal 1998 1998;316:823-828. Published:14-Mar-1998. PMID:9549452. doi:10.1136/bmj.316.7134.823

United Kingdom Prospective Diabetes Study, 30: diabetic retinopathy at diagnosis of non-insulin-dependent diabetes mellitus and associated risk factors
Archives of Ophthalmology 1998;116:297-303. Published:Mar-1998. PMID:9514482. doi:10.1001/archopht.116.3.297

United Kingdom Prospective Diabetes Study 24: a 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy
Annals of internal medicine 1998;128:165-175. Published:01-Feb-1998. PMID:9454524. doi:10.7326/0003-4819-128-3-199802010-00001

UKPDS 28: a randomized trial of efficacy of early addition of metformin in sulfonylurea-treated type 2 diabetes
Diabetes Care 1998;21:87-92. Published:Jan-1998. PMID:9538975. doi:10.2337/diacare.21.1.87


Progressive Hyperglycaemia: the UKPDS Experience
Holman RR
Consultant (Supp) 1997;37:530-536. Published:11-Sep-2006

UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes
Lancet 1997;350:1288-1293. Published:01-Nov-1997. PMID:9357409. doi:10.1016/S0140-6736(97)03062-6
Erratum in :
Lancet 1998;351:376, Print:31-Jan-1998, doi:10.1016/S0140-6736(05)78287-8

U.K. Prospective Diabetes Study 27. Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex
Diabetes Care 1997;20:1683-1687. Published:Nov-1997. PMID:9353608. doi:10.2337/diacare.20.11.1683

U.K. Prospective Diabetes Study 22. Effect of age at diagnosis on diabetic tissue damage during the first 6 years of NIDDM
Diabetes Care 1997;20:1435-1441. Published:Sep-1997. PMID:9283793. doi:10.2337/diacare.20.9.1435

UKPDS 20: plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects
J Clin Endocrinol Metab 1997;82:654-657. Published:Feb-1997. PMID:9024271. doi:10.1210/jcem.82.2.3744

UKPDS 21: low prevalence of the mitochondrial transfer RNA gene (tRNA(Leu(UUR))) mutation at position 3243bp in UK Caucasian type 2 diabetic patients
Saker PJ, Hattersley AT, Barrow B, Hammersley MS, Vorton H, Gillmer MD, Turner RC
Diab Med. 1997;14:42-45. Published:Jan-1997. PMID:9017352. doi:10.1002/(SICI)1096-9136(199701)14:1<42::AID-DIA295>3.0.CO;2-T


UKPDS 19: Heterogeneity in NIDDM: separate contributions of IRS-1 and b3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations
Zhang Y, Wat N, Stratton IM, Warren-Perry MG, Orho M, Groop L, Turner RC
Diabetolgia 1996;39:1505-1511. Published:Dec-1996. PMID:8960833. doi:10.1007/s001250050605

UKPDS 18: estimated dietary intake in type 2 diabetic patients randomly allocated to diet, sulphonylurea or insulin therapy
Diab Med. 1996;13:656-662. Published:Jul-1996. PMID:8840101. doi:10.1002/(SICI)1096-9136(199607)13:7<656::AID-DIA131>3.0.CO;2-5

United Kingdom Prospective Diabetes Study 17: a 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus
Annals of Internal Medicine 1996;124:136-145. Published:01-Jan-1996. PMID:8554206. doi:10.7326/0003-4819-124-1_Part_2-199601011-00011


U.K. Prospective Diabetes Study XV: Relationship of renin-angiotensin system gene polymorphisms with microalbuminuria in NIDDM
Dudley CRK, Keavney B, Stratton IM, Turner RC
Kidney International 1995;48:1907-1911. Published:Dec-1995. PMID:8587251. doi:10.1038/ki.1995.490

U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease
Diabetes 1995;44:1249-1258. Published:Nov-1995. PMID:7589820. doi:10.2337/diab.44.11.1249

UK prospective diabetes study (UKPDS) 14: association of angiotensin-converting enzyme insertion/deletion polymorphism with myocardial infarction in NIDDM
Keavney BD, Dudley CRK, Stratton IM, Holman RR, Matthews DR, Ratcliffe PJ, Turner RC
Diabetologia 1995;38:948-952. Published:Aug-1995. PMID:7589881. doi:10.1007/BF00400584

Relative Efficacy of Randomly allocated Diet, Sulphonylurea, Insulin, or Metformin in Patients with newly diagnosed non-insulin dependent diabetes followed for three years
Holman RR, Cull CA, Fox C, Turner RC
British Medical Journal 1995;310:83-88. Published:14-Jan-1995. PMID:7833731. doi:10.1136/bmj.310.6972.83

UK Prospective Diabetes Study: 3-year update
Holman RR for the UKPDS Group
New Horizons in Diabetes Mellitus and Cardiovascular Disease. In Current Science. Ed. Schwartz CJ, Born GVR. ISBN 1-85873-051-1 1995;183-186. Published:Jan-1995


UK Prospective Diabetes Study. XII: Differences between Asian, Afro-Caribbean and white Caucasian type 2 diabetic patients at diagnosis of diabetes
Meyer LC, Manley SE, Frighi V, Burden F, Neil HAW, Holman RR, Turner RC
Diab Med. 1994;11:670-677. Published:Aug-1994. PMID:7955993. doi:10.1111/j.1464-5491.1994.tb00331.x

UK Prospective Diabetes Study (UKPDS). XI: Biochemical risk factors in type 2 diabetic patients at diagnosis compared with age-matched normal subjects
Manley SE, Meyer LC, Neil HAW, Ross IS, Turner RC, Holman RR
Diab Med. 1994;11:534-544. Published:Jul-1994. PMID:7955969. doi:10.1111/j.1464-5491.1994.tb02032.x


L'Etude UKPDS Sur Le Controle De La Glycemie Et De L'Hypertension Arterielle Dans Le Diabete De type 2: Objectifs, Structure Et Resultats Preminiaires [The UKPDS study on glycemic control and arterial hypertension in type II diabetes: objectives, structure and preliminary results]
Levy JC, Cull CA, Stratton IM, Holman RR, Turner RC
Journ Annu Diabetol Hotel Dieu 1993;123-37. Published:11-Sep-2006. PMID:8331860

UK Prospective Diabetes Study (UKPDS). X. Urinary albumin excretion over 3 years in diet-treated type 2, (non-insulin-dependent) diabetic patients, and association with hypertension, hyperglycaemia and hypertriglyceridaemia
Cull CA, Manley S, Frighi V, Holman RR, Turner RC
Diabetologia 1993;36:1021-1029. Published:Oct-1993. PMID:8243850. doi:10.1007/BF02374494

UK Prospective Diabetes Study (UKPDS). IX: Relationships of urinary albumin and N-acetylglucosaminidase to glycaemia and hypertension at diagnosis of type 2 (non-insulin-dependent) diabetes mellitus and after 3 months diet therapy
UKPDS Study Group
Diabetologia 1993;36:835-842. Published:Sep-1993. PMID:8405755. doi:10.1007/BF00400359


UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance
Turner RC, Holman RR, Matthews DR, Oakes SF, Bassett PA, Stratton IM, Cull CA, Manley SE, Frighi V
Diabetologia 1991;34:877-890. Published:Dec-1991. PMID:1778353. doi:10.1007/BF00400195


Response of fasting plasma glucose to diet therapy in newly-presenting Type 2 diabetic patients
UKPDS Study Group
Metabolism 1990;39:905-912. Published:Sep-1990. PMID:2392060. doi:10.1016/0026-0495(90)90299-R

UK Prospective Diabetes Study 6. Complications in newly diagnosed type 2 diabetic patients and their association with different clinical and biochemical risk factors
UKPDS Study Group
Diabetes Research 1990;13:1-11. Published:Jan-1990. PMID:2097090
[Full text] [Abstract]


Characteristics of newly presenting type 2 diabetic patients: estimated insulin sensitivity and islet beta-cell function
UKPDS Study Group
Diab Med. 1988;5:444-448. Published:Jul-1988. PMID:2970917. doi:10.1111/j.1464-5491.1988.tb01025.x

Characteristics of newly-presenting type 2 diabetic patients: male preponderance and obesity at different ages
UKPDS Study Group
Diab Med. 1988;5:154-159. Published:Mar-1988. PMID:2964982. doi:10.1111/j.1464-5491.1988.tb00963.x


United Kingdom Prospective Diabetes Study. III. Prevalence of hypertension and hypotensive therapy in patients with newly diagnosed diabetes. A multicenter study
UKPDS Study Group
Hypertension 1985;7:11-13. Published:Nov-1985. PMID:4077242. doi:10.1161/01.HYP.7.6_Pt_2.II8

U.K. prospective diabetes study. II. Reduction in HbA1c with basal insulin supplement, sulfonylurea, or biguanide therapy in maturity-onset diabetes. A multicenter study
UKPDS Study Group
Diabetes 1985;34:793-798. Published:Aug-1985. PMID:2862087. doi:10.2337/diab.34.8.793


UK prospective study of therapies of maturity-onset diabetes. I. Effect of diet, sulphonylurea, insulin or biguanide therapy on fasting plasma glucose and body weight over one year
UKPDS Study Group
Diabetologia 1983;24:404-411. Published:Jun-1983. PMID:6350078. doi:10.1007/BF00257337